iscc.treatment.Immunotherapy ¶

Immunotherapy(immune_checkpoints, **kwargs)

Bases: Treatment

Immunotherapy: strips a cancer cell's immune resistance so the local immune microenvironment can kill it.

Unlike the death-rate therapies it does not kill directly — it lowers immune_resistance (by rate_multiplier ** -(1 - treatment_resistance), so cells that are also treatment-resistant are stripped less), and the killing is done by the local immune density in the death-rate model. With no immune_checkpoints given it acts on every cancer cell; otherwise only on cells expressing the listed checkpoints. Pass an instance to GenotypeTumor.grow(..., treatment=it).

Parameters:

Name	Type	Description	Default
`immune_checkpoints`	`list`	Checkpoint sites a cell must express to be targeted; empty = broad (every cancer cell is a target).	required
`**kwargs`		Forwarded to the `Treatment` base. See `Treatment` for the shared dosing / scheduling parameters (`start`, `duration`, `rate_multiplier`, `effectiveness`, ...).	`{}`

Methods:

Name	Description
`discrete_event`	One-shot state edits that are NOT rate modifiers (e.g. surgical resection). The base

discrete_event ¶

discrete_event(tumor, step)

One-shot state edits that are NOT rate modifiers (e.g. surgical resection). The base treatment does nothing; Surgery overrides this. The engine calls it once per step, so chemo-only / no-surgery runs stay byte-identical (no state change, no rng draw).